IVIg for relapsing–remitting multiple sclerosis: promises and uncertainties
نویسندگان
چکیده
منابع مشابه
Neuronal network analyses: premises, promises and uncertainties.
Neuronal networks assemble the cellular components needed for sensory, motor and cognitive functions. Any rational intervention in the nervous system will thus require an understanding of network function. Obtaining this understanding is widely considered to be one of the major tasks facing neuroscience today. Network analyses have been performed for some years in relatively simple systems. In ...
متن کاملTreatment of multiple sclerosis with IVIg: potential effects and methodology of clinical trials.
There is extensive evidence that immune mechanisms are involved in the pathogenesis of multiple sclerosis (MS). A potential treatment effect of IVIg in MS could be mediated by several mechanisms as IVIg is able to modulate the immune response in different ways. The evidence of the effect of IVIg in MS is at present based on the results of small open trials, some of which have been encouraging. ...
متن کاملPharmacokinetics and pharmacodynamics of peginterferon beta-1a in patients with relapsingremitting multiple sclerosis in the randomized ADVANCE study
AIMS To evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of subcutaneous peginterferon beta-1a in patients with relapsing-remitting multiple sclerosis (RRMS) in the phase 3 ADVANCE study (n = 1512). METHODS During year 1, patients were randomized (1:1:1) to placebo or peginterferon beta-1a 125 μg every 2 or 4 weeks. After year 1, patients randomized to placebo were re-randomized t...
متن کاملThe ethical turn in anthropology Promises and uncertainties
Do human beings act morally because they obey socially defined rules and norms as the result of a routine of inculcated behaviors, or an embodied fear of sanction, or perhaps both? Conversely, do they act morally because they decide to do so as a consequence of a rational evaluation, or transformative endeavor, or inseparably both? In other words, do they follow a Kantian ethics of duty or an A...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Pharmacological Sciences
سال: 2015
ISSN: 0165-6147
DOI: 10.1016/j.tips.2015.04.012